The human tumour suppressor protein p53 is critical for regulation of the cell cycle on genotoxic insult. When DNA is damaged by radiation, chemicals or viral infection, cells respond rapidly by arresting the cell cycle. A G1 arrest requires the activity of wild‐type p53, as it is not observed in cells lacking functionally wild‐type protein, and at least some component of S phase and G2/M arrests is also thought to be p53‐dependent. p53 functions as a transcription factor which binds specific (...) DNA sequences, and recently major downstream targets have been identified, including p21Cip1 an inhibitor of the cell cycle kinases that also blocks the replicative but not the repair function of DNA polymerase δ auxiliary factor, PCNA. Current interest focuses on developing novel cancer therapies based on our knowledge of the activity of p53 and p21Cip1 in the cell cycle. (shrink)

This chapter contains sections titled: The correspondence view Accounting for the two theses Implications.

Gestures are a special sort of action. They communicate the individual's moods and desires to the world and they operate under different psychological and cognitive constraints to other actions. The connections between gesture and language - spoken and signed - pose some fascinating questions. How intimately are gesture and language connected? Did one evolve from the other? To what extent are they similarly processed in the brain? In what ways are signed languages akin to spoken language and gestures? Gesture, Speech, (...) and Sign examines these questions, bringing together an international array of expertise to explore the origins, neurobiology, and uses of these three communication systems. A unique feature of the book is its discussion of how a greater understanding of these issues can be used to improve human-computer interactions. Designed to appeal to a multi-disciplinary audience Gesture, Speech, and Sign will be of interest to advanced students and researchers in neuroscience, psychology, linguistics, computer science, and those involved in deaf studies. (shrink)

Following the highly publicized New Bedford rape case, in which a young woman was raped by several men on a pool table in New Bedford, Massachusetts, on March 6, 1983, a segment of the local Portuguese community responded with great hostility to the rape victim and with sympathy for the rapists. The victim was blamed for the ethnic prejudice that erupted after the rape and culminated in the trial of six rapists in 1984. This article's purpose is to analyze the (...) Portuguese community's response, particularly the negative reactions of Portuguese women to another Portuguese woman who had been raped, and the conflict that developed between ethnic and sexual forms of prejudice. (shrink)

The philosopher Donald Davidson has argued in an influential article, “On the Very Idea of a Conceptual Scheme,” that there is no intelligible basis on which to distinguish between conceptual schemes that Kuhn and Feyerabend have treated as incommensurable or incompatible. He concludes that, given the underlying methodology of interpretation of speech behavior, we cannot be in a position to judge that others have concepts or beliefs radically different from our own. Thus, he adds, we cannot talk meaningfully about the (...) existence of conceptual schemes. I offer a historical rejoinder to Davidson, focusing on the famous seventeenth-century debate between Descartes and Gassendi regarding the use of the first-person pronoun. I show that, in this particular debate, their failure to translate the pronoun “I” was so basic and fundamental a failure that, although it turned on just one word, it forced Gassendi to question the longstanding Renaissance humanist principle of the intertranslatability of all natural languages. Could the Gassendi-Descartes debate similarly challenge Davidson’s assertion of the intertranslatability of all natural languages and his consequent denial of the existence of conceptual schemes? (shrink)

This volume is fourth in the series of annuals created under the auspices of The Association for Feminist Ethics and Social Theory . The topics covered herein_from peacekeeping and terrorism, to sex trafficking and women's paid labor, to poverty and religious fundamentalism_are vital to women and to feminist movements throughout the world.

Americans cherish the idea that good eventually triumphs over evil. After briefly arguing that a proper understanding of the moral harm of cruelty calls into question the credibility of popular American idioms of redemption, I argue that the epistemic dynamics of horror help account for the commanding grip of this rhetoric on the popular imagination, and I suggest that this idiom has morally problematic features that warrant the attention of feminists.

Human flourishing is the topic of an increasing number of books and articles in educational philosophy. Flourishing should be regarded as an ideal aim of education. If this is defended, the first step should be to elucidate what is meant by flourishing, and what exactly the concept entails. Listing formal criteria can facilitate reflection on the ideal of flourishing as an aim of education. We took Aristotelian eudaimonia as a prototype to construct two criteria for the concept of human flourishing: (...) human flourishing is regarded as intrinsically worthwhile and flourishing means ‘actualisation of human potential’. The second criterion has three sub-criteria: flourishing is about a whole life, it is a ‘dynamic state’ and flourishing presupposes there being objective goods. (shrink)

(1996). Photomechanical tendencies in Giorgio de Chirico's Melancholy vision. The European Legacy: Vol. 1, Fourth International Conference of the International Society for the Study of European Ideas, pp. 1310-1315.

What happens during a near-death experience? In an accessible style, this text reviews recent research about unbelievable events, creating an account of activity at the boundaries of science. It also examines research concerns, current theories, methodological issues and clinical implications.

Canada’s commercial seal hunt has been the subject of controversy for over 40 years. Much of the debate has centered on the question of humane killing. The reality, however, is that debates about commercial sealing are political debates involving conflicting values and ethics. We argue that the time has come for conservationists, scientists, managers of free-living animals, bureaucrats, politicians, and society at large to think beyond populations and ecosystems and consider also the well-being of individual, sentient animals. The fundamental question (...) then becomes, “Can commercial seal hunts be morally justified in the twenty-first century?”. (shrink)

The PEIRCE EDITION contains large sections of previously unpublished material in addition to selected published works. Each volume includes a brief historical and biographical introduction, extensive editorial and textual notes, and a full chronological list of all of Peirce’s writings, published and unpublished, during the period covered.

Moral reflections: David Harvey's justice, nature and the geography of difference. Malden, MA and Oxford: Blackwell, 1996. 468 pp., paper/cloth, $25.95/$68.95, ISBN 1-55786-681-3/1-55786-680-5.

At its inception, the training model in the Graduate School of Clinical Psychology at George Fox University was informed by the approach inaugurated at Fuller Theological Seminary School of Psychology in the 1960s. In the original model, training in Christian religion/spirituality and theology accompanied training in professional psychology. In the interim, our culture, psychological knowledge, perceived psychological needs, and training programs have changed greatly. Here we report changes in religion/spirituality training and integration over the last two decades. We describe our (...) current spiritual formation structure and process, and program evaluation efforts. Over the past several years the GSCP has shifted from relying mainly on a cognitive approach involving Bible and theology courses toward a more personal-experiential approach that includes team teaching of the theology and religion courses, an individualized spiritual direction experience spread over two years, and more intentional integration of R/s and spiritual formation components throughout the program. We anticipate this may be an ongoing area for further development in coming years as we seek to meet the needs of a changing student body with greater R/s diversity and largely postmodern worldviews. (shrink)

(2003). Act of Ethics: A Special Section on Ethics and Global Activism. Ethics, Place & Environment: Vol. 6, No. 1, pp. 43-78.

Unrealistic optimism is a bias that leads people to believe, with respect to a specific event or hazard, that they are more likely to experience positive outcomes and/or less likely to experience negative outcomes than similar others. The phenomenon has been seen in a range of health-related contexts—including when prospective participants are presented with the risks and benefits of participating in a clinical trial. In order to test for the prevalence of unrealistic optimism among participants of early-phase oncology trials, we (...) conducted a survey with patients over 18 years of age who were enrolled in a phase I, phase I/II, or phase II clinical cancer trial in the New York City area between August 2008 and October 2009. Participants in our study were asked to compare their own chances of experiencing a range of risks and benefits related to the trial they were enrolled in with the chances of the other trial participants. We found a significant optimistic bias in their responses. Respondents tended to overestimate the benefits of the trial they were enrolled in and underestimate its risks. In addition, we found no significant relationship between respondents’ understanding of the trial’s purpose and how susceptible they were to unrealistic optimism. Our findings suggest that improving the consent process for oncology studies requires more than addressing deficits in understanding. (shrink)

This investigation examined whether speakers produce reliable prosodic correlates to meaning across semantic domains and whether listeners use these cues to derive word meaning from novel words. Speakers were asked to produce phrases in infant‐directed speech in which novel words were used to convey one of two meanings from a set of antonym pairs (e.g., big/small). Acoustic analyses revealed that some acoustic features were correlated with overall valence of the meaning. However, each word meaning also displayed a unique acoustic signature, (...) and semantically related meanings elicited similar acoustic profiles. In two perceptual tests, listeners either attempted to identify the novel words with a matching meaning dimension (picture pair) or with mismatched meaning dimensions. Listeners inferred the meaning of the novel words significantly more often when prosody matched the word meaning choices than when prosody mismatched. These findings suggest that speech contains reliable prosodic markers to word meaning and that listeners use these prosodic cues to differentiate meanings. That prosody is semantic suggests a reconceptualization of traditional distinctions between linguistic and nonlinguistic properties of spoken language. (shrink)